| Purity | ≥99% |
| Molecular Weight | 403 Da |
| Category | Copper-binding tripeptide / Tissue-remodeling and antioxidant peptide |
| Sequence | Gly-His-Lys, complexed with Cu(II) |
GHK-Cu
A naturally occurring copper-binding tripeptide studied for its roles in collagen synthesis, tissue remodeling, and antioxidant activity.
Starting from $55.00
For research use only. Not for human consumption.
Storage Conditions
Store lyophilized powder at −20 °C. After reconstitution, store at 4 °C and use within 28 days. Avoid repeated freeze-thaw cycles.
Research Overview
GHK-Cu was first identified in human plasma in the 1970s by Loren Pickart, who observed that plasma from younger individuals had a greater capacity to stimulate liver cell growth in culture than plasma from older individuals — an effect later traced to GHK-Cu. Circulating GHK-Cu levels have since been reported to decline substantially with age.
Subsequent decades of research, much of it led by Pickart and collaborators, characterized GHK-Cu's effects on collagen synthesis, wound healing, and gene expression, including genomic profiling studies identifying broad transcriptional effects on genes involved in tissue repair. Maquart et al. (1993) provided early biochemical evidence that GHK-Cu directly stimulates collagen synthesis in fibroblast culture.
GHK-Cu has been most extensively studied in dermatological and cosmetic research, where it is a common ingredient in topical formulations studied for skin firmness, wrinkle appearance, and wound healing. Research has also examined hair-follicle and systemic applications. As with most cosmeceutical peptides, most published human data comes from smaller clinical and observational studies rather than large randomized controlled trials.
Research use only. This product is intended for in vitro and laboratory research purposes only. It is not approved by the FDA for human or veterinary use. It is not a drug, food, or cosmetic, and may not be misbranded, misused, or sold for purposes other than research.
All information provided is for research and educational purposes only and does not constitute medical advice.