| Purity | ≥99% |
| Molecular Weight | 1,815 Da |
| Category | Modified 16-amino-acid hGH fragment / Lipolytic peptide |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (hGH 176–191 fragment, Phe176→Tyr substitution, Cys7–Cys15 disulfide bridge) |
AOD-9604
A modified 16-amino-acid fragment of human growth hormone studied for lipolytic effects without the growth-promoting activity of full-length hGH.
Starting from $50.00
For research use only. Not for human consumption.
Storage Conditions
Store lyophilized powder at −20 °C. After reconstitution, store at 4 °C and use within 28 days. Avoid repeated freeze-thaw cycles.
Research Overview
AOD-9604 was developed by Monash University researchers and licensed to Metabolic Pharmaceuticals in the 1990s, based on earlier research identifying the hGH 176–191 fragment as the region responsible for the hormone's lipolytic, non-growth-promoting activity.
Metabolic Pharmaceuticals advanced AOD-9604 through six human clinical trials involving more than 900 participants, studying both subcutaneous (0.25, 0.5, and 1 mg daily) and oral (1, 5, 10, and 20 mg daily) dosing over periods up to 24 weeks. The subcutaneous 500 mcg/day dose was reported to show the most favorable efficacy-to-safety balance in early trials.
However, AOD-9604's largest Phase IIb trial failed to reach statistical significance for its primary weight-loss endpoint, and Metabolic Pharmaceuticals discontinued clinical development of the compound as an obesity treatment in 2007. It has not been approved by the FDA or any equivalent regulatory body for any indication. Research interest in AOD-9604 has since continued primarily in preclinical and mechanistic settings, including cartilage and joint-health research, rather than late-stage clinical development.
Research use only. This product is intended for in vitro and laboratory research purposes only. It is not approved by the FDA for human or veterinary use. It is not a drug, food, or cosmetic, and may not be misbranded, misused, or sold for purposes other than research.
All information provided is for research and educational purposes only and does not constitute medical advice.